Artikel Review: Drug Related Problems Pada Penggunaan Terapi Antidiabetik Oral dan Insulin Pada Penderita Diabetes Mellitus Tipe 2
DOI:
https://doi.org/10.59024/jikas.v4i2.1667Keywords:
Combination Therapy, Drug-Related Problems, Insulin, Oral Antidiabetic Agents, Type 2 Diabetes MellitusAbstract
Drug-Related Problems (DRPs) are common in patients with type 2 Diabetes Mellitus (T2DM) who receive combination therapy involving oral antidiabetic agents and insulin. This literature review aims to identify the main types of DRPs and the factors contributing to their occurrence based on recent studies from PubMed, ScienceDirect, ResearchGate, and Google Scholar. The most frequently reported DRP is drug interaction, followed by underdosing, overdosing, therapy without indication, untreated indications, adverse drug reactions, and patient-related problems such as non-adherence. Several factors contribute to the occurrence of DRPs, including polypharmacy, inappropriate dosing, the presence of comorbidities, limited patient knowledge regarding therapy, and inadequate clinical monitoring. These conditions may increase the risk of poor glycemic control and treatment failure. Therefore, effective management of DRPs is essential to improve therapeutic outcomes. The findings of this review emphasize the important role of pharmacists in conducting medication reviews, identifying DRPs early, and implementing appropriate interventions to enhance patient safety and optimize treatment in T2DM patients.
References
(2023). Determination of Drug-Related Problems Among Type 2 Diabetes Outpatients in A Hospital in Vietnam: A cross-sectional study. PLOS ONE, 18(8), e0289825. https://doi.org/10.1371/journal.pone.0289825
Abdu, S., Berhe, D. F., Tadesse, Y., Woldu, M. A., & Haile, D. (2021). Drug-related problems among patients with chronic diseases in the outpatient clinics of a tertiary care hospital in Ethiopia. BMC Health Services Research.
Alhaddad, M. S., Alzahrani, M. A., & Aljohani, N. J. (2019). Impact of clinical pharmacy services on preventing drug-related problems in hospital settings: A systematic review. Saudi Pharmaceutical Journal.
Alomar, M. J., Altaber, M., & Al Khaja, K. (2021). Prevalence of drug-related problems in patients with renal disease: A prospective study. International Journal of Clinical Pharmacy.
Ayalew, E., Tegegn, H. G., & Abdela, J. (2020). Drug-related problems among patients with type 2 diabetes mellitus in outpatient clinics of a university hospital. PLoS ONE. Dipiro. (2020). Past Editors Of Pharmacotherapy Editions 2-10.
Farqi, M. I., Windari, N. I., & Dirga (2025). Identification of Drug-Related Problems (DRPs) in Type 2 Diabetes Mellitus Patients with Chronic Kidney Disease (CKD) I-III in the inpatient ward of Hospital X, Bandar Lampung. Jurnal Sains dan Teknologi Farmasi Indonesia, 14(1):9-25. https://doi.org/10.58327/jstfi.v14i1.96
Fraga, A. D. S. S., Sinuor, C. M. O., & Bere, M. M. (2024). Identifikasi drug related problems (DRPs) potensi interaksi obat pada penggunaan terapi antidiabetes di Rumah Sakit St. Carolus Borromeus Kupang. Jurnal Farmagazine, 11(2), 1-7. https://doi.org/10.47653/farm.v11i2.708
Hartuti, S., Nasution, A., & Syafril, S. (2019). The Effect Of Drug-Related Problems On Blood Glucose Level In The Treatment Of Patients With Type 2 Diabetes Mellitus. Macedonian Journal of Medical Sciences, 7(11), 1798-1802. https://doi.org/10.3889/oamjms.2019.290
Huong, D. T. L., Hang, N. T., Ly, N. K., Nhat, N. H., Huong, N. T. L., Hue, L. T. P., Anh, D.
IDF. (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice,183, https://doi.org/10.1016/j.diabres.2021.109119
Jannah, M., & Lolok, N. (2025). Analisis Drug Related Problems (DRPs) Pada Pasien Rawat Jalan Diabetes Melitus Tipe 2 Di Puskesmas "X" Kota Kendari Periode Juli-Desember 2022. Jurnal Pharmacia Mandala Waluya, 4(1), 32-44. https://doi.org/10.54883/jpmw.v4i1.221
Latief, M. S. (2024). Drug Related Problems (DRPs) Penggunaan Obat Antidiabetik Pada Pasien Rawat Inap Diabetes Mellitus Tipe 2. Indonesian Journal of Health Science, 4(5). https://doi.org/10.54957/ijhs.v4i5.1089
Maimanah, S., Andarini, Y. D., & Kusumaningtyas, N. M. (2018). Identifikasi drug related problems (DRPs) pada pasien diabetes mellitus tipe 2 komplikasi hipertensi di RSUP Dr. Soeradji Tirtonogoro Klaten tahun 2018. Pharmaceutical Journal of Islamic Pharmacy, 2(1), 1-10.
Mawaddayanti, D., & Lolok, N. (2025). Analisis Drug Related Problems (DRPs) Pada Pasien Rawat Jalan Diabetes Melitus Tipe 2 Periode Januari-Juni 2023 di Rumah Sakit X. Jurnal Pharmacia Mandala Waluya, 4(4), 241-250. https://doi.org/10.54883/jpmw.v4i4.212
Murtiono & Ngurah I.G.K.G., 2020, Gambaran Asuhan Keperawatan Pada Pasien Hipertensi Dengan Gangguan Kebutuhan Rasa Nyaman Nyeri, Jurnal Poltekes Denpasar, 1 (13), 35 42, https://doi.org/10.33992/jgk.v13i1.1181
Ningrum, A. N., Hasanah, Y. I. F., Novitasari, M., & Taniar, B. S. S. (2023). Evaluasi DRPs dan Outcome Terapi Pada Pasien Diabetes Mellitus Tipe 2 Dengan Penyakit Penyerta Hipertensi Stage 2. Jurnal Farmasi Sains dan Teknologi, 1(01), 1-5. https://doi.org/10.65117/w8em5w81
PB PERKENI. (2021). Pedoman Pengelolaan Dan Pencegahan Diabetes Mellitus Tipe 2 Dewasa Di Indonesia-2021 Perkeni i Penerbit PB. Perkeni.
Putri, N. M. A., Fortuna, T. A., & Mendra, N. N. Y. (2024). Evaluasi drug related problem (DRPs) pada pasien demam tifoid di instalasi rawat inap RSU Islam Klaten periode November 2021-Oktober 2022. Usadha Journal of Pharmacy, 162-176. https://doi.org/10.23917/ujp.v3i2.318
Samanta, S., Bhat, W. H., George, J., & Ramaiah, B. (2025). Drug-related problems among type 2 diabetes mellitus patients with hypertension: A prospective observational study. International Journal of Basic & Clinical Pharmacology, 14 (2):213-218 https://doi.org/10.18203/2319-2003.ijbcp20250480
Sasmitha, D., & Fortuna, T. A. (2024). Evaluasi drug related problems pada pasien diabetes melitus tipe 2 di RS "X" Surakarta (Evaluation of drug related problems in type 2 diabetes mellitus patients at "X" Hospital Surakarta). Usadha: Journal of Pharmacy, 3(4), 1-10. https://doi.org/10.23917/ujp.v3i4.431
Sisay, M., Mengistu, G., Edessa, D., & Gebreyesus, F. (2020). Drug-related problems among patients with hypertension in ambulatory care settings: A cross-sectional study. Integrated Pharmacy Research and Practice.
T. L., Dung, B. T. K., Phuong, P. M., Lan, L. T., Tung, T. T., Hieu, N. N., & Ly, N. H.
Yitayeh, A., Yimam, M., & Alemu, B. (2021). Drug-related problems and their determinants among patients with chronic diseases in hospital outpatient departments. Frontiers in Pharmacology.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
