Efek Daidzein sebagai Isoflavon Utama Kedelai terhadap Kesehatan Tulang pada Wanita Menopause
(Literature Review)
DOI:
https://doi.org/10.59024/jikas.v4i1.2669Keywords:
Bone Mineral Density, Bone Health, Daidzein, Postmenopausal Women, Soy IsoflavonesAbstract
Daidzein is a soy-derived isoflavone that has been widely investigated as a potential non-hormonal alternative for preventing osteoporosis in postmenopausal women. This literature review aims to analyze the effects of daidzein supplementation on bone health based on findings from various studies. The reviewed evidence indicates that most studies have reported improvements in Bone Mineral Density (BMD), particularly in the lumbar spine, as well as favorable changes in bone remodeling biomarkers. Isoflavone supplementation has been associated with increased levels of bone formation markers, such as osteocalcin and bone-specific alkaline phosphatase (BALP), and decreased levels of bone resorption markers, such as C-terminal telopeptide of type I collagen (CTX), suggesting a potential osteoprotective effect. However, the findings remain inconsistent. Some studies have reported no statistically significant effects, potentially due to variations in dosage, intervention duration, and individual metabolic status. Limitations related to sample size, measurement methods, and population heterogeneity further restrict the generalizability of the findings. Overall, daidzein and soy isoflavones show potential as complementary agents for maintaining bone health in postmenopausal women. Nevertheless, further standardized, long-term studies are needed to establish their clinical efficacy and safety.
References
Akhlaghi, M., Ghasemi Nasab, M., Riasatian, M., & Sadeghi, F. (2020). Soy isoflavones prevent bone resorption and loss, a systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 60(14), 2327–2341. https://doi.org/10.1080/10408398.2019.1635078
Alshehri, M. M., Sharifi-Rad, J., Herrera-Bravo, J., Jara, E. L., Salazar, L. A., Kregiel, D., Uprety, Y., Akram, M., Iqbal, M., Martorell, M., Torrens-Mas, M., Pons, D. G., Daştan, S. D., Cruz-Martins, N., Ozdemir, F. A., Kumar, M., & Cho, W. C. (2021). Therapeutic potential of isoflavones with an emphasis on daidzein. Oxidative Medicine and Cellular Longevity, 2021, Article 6331630. https://doi.org/10.1155/2021/6331630
Fink, H. A., MacDonald, R., Forte, M. L., Rosebush, C. E., Ensrud, K. E., Schousboe, J. T., Nelson, V. A., Ullman, K., Butler, M., Olson, C. M., Taylor, B. C., Brasure, M., & Wilt, T. J. (2019). Long-term drug therapy and drug discontinuations and holidays for osteoporosis fracture prevention: A systematic review. Annals of Internal Medicine, 171(1), 37–50. https://doi.org/10.7326/M19-0533
Jia, J., He, R., Yao, Z., Su, J., Deng, S., Chen, K., & Yu, B. (2023). Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling. PeerJ, 11, Article e16121. https://doi.org/10.7717/peerj.16121
Karieb, S. S., Jawad, M. M., Al-Shmgani, H. S., & Kadri, Z. H. M. (2016). The effect of the combination of vitamin K2 and genistein, coumestrol and daidzein on the osteoblast differentiation and bone matrix formation. Journal of Biotechnology Research Center, 10(2), 12–19. https://doi.org/10.24126/jobrc.2016.10.2.474
Kenny, A. M., Mangano, K. M., Abourizk, R. H., Bruno, R. S., Anamani, D. E., Kleppinger, A., Walsh, S. J., Prestwood, K. M., & Kerstetter, J. E. (2009). Soy proteins and isoflavones affect bone mineral density in older women: A randomized controlled trial. The American Journal of Clinical Nutrition, 90(1), 234–242. https://doi.org/10.3945/ajcn.2009.27600
Lee, H., Choue, R., & Lim, H. (2017). Effect of soy isoflavones supplement on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women: A randomized clinical trial. Nutrition Research and Practice, 11(3), 223–231. https://doi.org/10.4162/nrp.2017.11.3.223
Liu, Z. M., Chen, B., Li, S., Li, G., Zhang, D., Ho, S. C., Chen, Y. M., Ma, J., Qi, H., & Ling, W. H. (2020). Effect of whole soy and isoflavones daidzein on bone turnover and inflammatory markers: A 6-month double-blind, randomized controlled trial in Chinese postmenopausal women who are equol producers. Therapeutic Advances in Endocrinology and Metabolism, 11, 1–14. https://doi.org/10.1177/2042018820920555
Liu, Z. M., Ho, S. C., Chen, Y. M., Tang, N., & Woo, J. (2014). Effect of whole soy and purified isoflavone daidzein on renal function—A 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension. Clinical Biochemistry, 47(13–14), 1250–1256. https://doi.org/10.1016/j.clinbiochem.2014.05.054
Nayeem, F., Chen, N. W., Nagamani, M., Anderson, K. E., & Lu, L. J. W. (2019). Daidzein and genistein have differential effects in decreasing whole body bone mineral density but had no effect on hip and spine density in premenopausal women: A 2-year randomized, double-blind, placebo-controlled study. Nutrition Research, 68, 70–81. https://doi.org/10.1016/j.nutres.2019.06.007
Öztürk Turhan, N., Bolkan, F., Iltemir Duvan, C., & Ardıçoğlu, Y. (2008). The effect of isoflavones on bone mass and bone remodelling markers in postmenopausal women. Turkish Journal of Medical Sciences, 38(2), 145–152.
Pawlowski, J. W., Martin, B. R., McCabe, G. P., McCabe, L., Jackson, G. S., Peacock, M., Barnes, S., & Weaver, C. M. (2015). Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: A randomized crossover trial. The American Journal of Clinical Nutrition, 102(3), 695–703. https://doi.org/10.3945/ajcn.114.093906
Salam, M. A., Raslan, H. M., Mohamed, D. A., Elgendy, A., Hussein, R. A., Moguib, O., Abdelhadi, M., El-Banna, R. A. E. S. S., Fouda, K., El Sherity, S. Y., Zikri, E. N., & Ammar, N. M. (2021). Effect of soybean on bone health and some metabolic parameters in postmenopausal Egyptian women. Pharmacognosy Journal, 13(3), 688–697. https://doi.org/10.5530/pj.2021.13.88
Sansai, K., Na Takuathung, M., Khatsri, R., Teekachunhatean, S., Hanprasertpong, N., & Koonr N. (2021). Effects of soy isoflavones on biochemical markers of bone metabolism in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials. International Journal of Environmental Research and Public Health, 18(10), Article 5346. https://doi.org/10.3390/ijerph18105346
Tai, T. Y., Tsai, K. S., Tu, S. T., Wu, J. S., Chang, C. I., Chen, C. L., Shaw, N. S., Peng, H. Y., Wang, S. Y., & Wu, C. H. (2012). The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: A 2-year randomized double-blind placebo-controlled study. Osteoporosis International, 23(5), 1571–1580. https://doi.org/10.1007/s00198-011-1750-7
Wei, P., Liu, M., Chen, Y., & Chen, D. C. (2012). Effects of isoflavone interventions on bone mineral density in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials. Osteoporosis International. https://pubmed.ncbi.nlm.nih.gov/32524173/
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